Long-term Outcome of Patients with Hypertrophic Cardiomyopathy

pp. 215-220

Abstract

Background: Hypertrophic cardiomyopathy is a complex disease that for years has been associated with high rates of morbidity and mortality. However, most of the available information on its outcome is based on data generated from centers including selected, mainly high risk patients.

Objective: The purpose of this study was to evaluate the rate of events at follow-up of patients with hypertrophic cardiomyopathy in our setting.

Methods: A retrospective cohort of patients with hypertrophic cardiomyopathy was studied, assessing functional class and clinical event occurrence from echocardiographic and cardiac magnetic resonance imaging studies.

Results: A total of 259 patients with median follow-up of 3.5 years (2-10) were included in the study. Mean age was 56±16.8 years and 38.2% had obstructive forms of the disease. Sixty-seven percent of patients were in functional class I at follow-up onset. During the follow-up period, overall mortality rate was 1.6% with 1.1% sudden death or appropriate defibrillator shock and 6.6% of patients developed atrial fibrillation. The rate of in-hospital admission for acute heart failure was 5.8% and 14.3% of patients had functional class worsening. A total of 22 alcohol septal ablation and 15 myectomy procedures were performed with significant symptom improvement.

Conclusions: Follow-up of patients with hypertrophic cardiomyopathy showed low morbidity and mortality rate. The main adverse event was functional class worsening, followed by the development of atrial fibrillation and heart failure, with a low rate of sudden death.