Lipoprotein(a) and Coronary Artery Disease

pp 533-541

Abstract

During the last few years strong evidence has linked lipoprotein(a) with the development of atherosclerosis. Plasma lipoprotein(a) is an independent predictor for the risk of myocardial infarction and, in addition, for the development of pre-mature coronary artery disease. Recent work in vitro, in vivo and with animal models have demonstrated the Fundamental role of lipoprotein (a) in the development of atherosclerosis. Futher more, clinical studies have now shown a close relation-ship between raised plasma lipoprotein(a) levels and the risk of restenosis following a coronary angioplasty, as well as angiographic extension and severity of coronary lesions to date, the therapeutic approaches for modifying this inherited risk factor are scarce. The future availability of agents being able to lower plasma lipoprotein(a) levels will clarify its role in the atherosclerotic process.