The lyrics, composed by songwriter Julio Numhauser and exquisitely performed by Mercedes Sosa, tell us that people, things, and the world change over time; everything can change except love for one's homeland. To some extent, this poetic expression is repeated in Argentina. Although changes occur constantly and rapidly, the history and serious consequences of myocardial infarction remain unchanged. Nothing has changed; everything remains invariably the same.
This statement is supported by the results of the ARGEN-IAM-ST registry, in a timeline spanning 10 uninterrupted years, where the most striking data were the high-hospital mortality rates, which remained persistent and unchanged throughout the decade. (1)
Going back to previous experiences, in 2010 the mortality rate of the 705 patients with STEMI admitted to centers with medical residency programs was also similar, close to 8%. (2)
International records, similar to national data in terms of reperfusion times and percentages, show lower mortality rates, ranging from 4.4% to 5.6% even in Latin American countries with similar socio-cultural characteristics. (3-5)
The epidemiological reality in Argentina is, in fact, even more alarming than these figures suggest, as the available data largely come from institutions with academic training. Unfortunately, there are few population-based surveys available. (6,7)
The dilemma is interpreting why, despite a high reperfusion rate and acceptable in-hospital times, there is no impact on mortality.
In general, this problem has multiple causes, which can be attributed to factors such as a paucity of hospital resources, a reduced availability of cardiac catheterization laboratories in low-income regions, and the presence of untrained and unmotivated staff.
Among the main reasons, the authors highlight "the long time to presentation, with a delay at least 50% longer than observed in other registries."
Total ischemic time, measured from the onset of symptoms to balloon inflation, was independently associated with all-cause in-hospital mortality.
In another registry, in patients with a time from the onset of symptoms to balloon inflation ≥ 361 minutes, the risk of mortality increased by 50% compared to those with a time from the onset of symptoms to balloon inflation ≤ 120 minutes. (8)
Furthermore, the high incidence of heart failure is related to a greater degree of myocardial injury due to prolonged ischemia. (9,10)
This reality clearly indicates the decline of the national healthcare system- or rather the lack of a system. It falls far short of the World Health Organization's (WHO) definition of a health system as "all organizations, people, and actions whose primary intent is to promote, restore, or maintain health. This includes medical services (hospitals, clinics), community-based actions, health policies, funding, and the health workforce." (11)
There is a consensus that ensuring the health of the population is a responsibility that extends beyond the direct actions of the health sector. It is the State as a whole that must serve as the guarantor of health through its comprehensive policies. (12)
This underscores the importance of implementing more efficient care networks in countries with limited resources and prioritizing health policies that ensure equitable and timely access to high-quality reperfusion strategies. (13)
In the contemporary context, the phrase "Argentines, attend to the realities!" articulated by the Spanish philosopher and essayist Jose Ortega y Gasset holds particular pertinence. It urges Argentines to set (14)
Conflicts of interest:
None declared. (See authors' conflict of interests forms on the website).
BIBLIOGRAFÍA
1. D'Imperio H, Gagliardi J, Charask A, Castillo Costa Y, Macin S, Zapata Z, et al. Mortality Patterns in ST-Segment Elevation Myocardial Infarction Over 10 Years in Argentina. ARGEN-IAM-ST Registry. Rev Argent Cardiol 2026;94:5-11. https://doi.org/10.7775/rac.v94.11.20967
2. Perez G, Costabel J, Gonzalez N, Zaidel E, Altamirano M, Schiavone M, et al. Acute Myocardial Infarction in Argentina. CONARC-EC XVII Registry. Rev Argent Cardiol 2013;81:390-9. https://doi.org/10.7775/rac.es.v81.15.1391
3. Zeymer U, Ludman P, Danchin N, Kala P, Laroche C, Sadeghi M, et al. ACVC EAPCI EORP ACS STEMI investigators group of the ESC. Reperfusion therapies and in-hospital outcomes for ST elevation myocardial infarction in Europe: the ACVC-EAPCI EORP STEMI Registry of the European Society of Cardiology. Eur Heart J 2021;42:4536-49. https://doi.org/10.1093/eurheartj/ehab342
4. Steg PG, Dabbous OH, Feldman LJ, Cohen-Solal A, Aumont MC, Lopez-Sendon J, et al. Determinants and Prognostic Impact of Heart Failure Complicating Acute Coronary Syndromes: Observations From the Global Registry of Acute Coronary Events (GRACE). Circulation 2004;109:494-9. https://doi.org/10.1161/01.CIR.0000109691.16944.DA
5. Quintana M, Perea J, Villarreal R, Lopez Ruiz A, Arias A, Quispe Y, et al. ST-segment elevation acute myocardial infarction in the Americas: results from the Latin STEMI registry. Rev Intern Cardiol. 2025;2:7-14. https://doi.org/10.24875/RIAC.25000005
6. Caccavo A, Alvarez A, Bello FH, Ferrari AE, Carrique AM, Ladisca SA, et al. Eleven Years Incidence of Infarction with STElevation or Left Bundle Branch Block on the Population of a Community in the Province of Buenos Aires. Rev Argent Cardiol 2007;75:185-8.
7. Calandrelli ME, Caminos M, Bocian JL, Saavedra ME, Zgaib ME, Bazán A, et al. Annual Incidence and Lethality of Acute Myocardial Infarction in the City of San Carlos de Bariloche. The REGIBAR Study. Rev Argent Cardiol 2017;85:428-34.
8. Gao N, Qi X, Dang Y, Li Y, Wang G, Liu X, et al. Association between total ischemic time and in-hospital mortality after emergency PCI in patients with acute ST-segment elevation myocardial infarction: a retrospective study. BMC Cardiovasc Disord 2022;22:80. https://doi.org/10.1186/s12872-022-02526-8
9. Shiomi H, Nakagawa Y, Morimoto T, Furukawa Y, Nakano A, Shirai S, et al. Association of onset to balloon and door to balloon time with long term clinical outcome in patients with ST elevation acute myocardial infarction having primary percutaneous coronary intervention: observational study. BMJ 2012;344:e3257. https://doi.org/10.1136/bmj.e3257
10. Prasad A, Gersh BJ, Mehran R, Brodie BR, Brener SJ, Dizon JM, et al. Effect of ischemia duration and door-to-balloon time on myocardial perfusion in ST-segment elevation myocardial infarction: an analysis from HORI ZONS-AMI trial (harmonizing outcomes with revascularization and stents in acute myocardial infarction). JACC Cardiovasc Interv 2015;8:1966-74. https://doi.org/10.1016/j.jcin.2015.08.031
11. Organizacion Mundial de la Salud (OMS). Sistemas de salud [Internet] [access: 6 de mayo del 2015]. http://www.who.int/topics/health_systems/es/
12. Octava Conferencia Mundial de Promoción de la Salud. Helsinki, 10-14 de junio del 2013 [Internet]. http://www.mspbs.gov.py/promociondelasalud/wp-content/uploads/2013/08/Octava-Helsinki.pdf
13. Allin J, Barrero C, Botto F, Charask A, Chavez I, DI Tommasso F, et al. Realidad del manejo del infarto agudo de miocardio con elevación del segmento ST en la Argentina. Rev Argent Cardiol 2008;76:226-8.
14. Meditación del pueblo joven y otros ensayos sobre Latinoamérica. José Ortega y Gasset. Biblioteca de la Revista de Occidente. Editorial Emcee. Año 1958